ParkinsonFranceV1, Main, Exploration, bibRecord, 001929

Pathological roles of MAPK signaling pathways in human diseases

Identifieur interne : 001929 ( Main/Exploration ); précédent : 001928; suivant : 001930

Pathological roles of MAPK signaling pathways in human diseases

Auteurs : Eun Kyung Kim [Corée du Sud] ; Eui-Ju Choi [Corée du Sud]

Source :

BBA - Molecular Basis of Disease [ 0925-4439 ] ; 2010-02-17.

RBID : Hal:hal-00566733

Abstract

The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular signal-regulated kinase (ERK), p38, and c-Jun NH-terminal kinase (JNK), with each MAPK signaling pathway consisting of at least three components, a MAPK kinase kinase (MAP3K), a MAPK kinase (MAP2K), and a MAPK. The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress. These signaling pathways regulate a variety of cellular activities including proliferation, differentiation, survival, and death. Deviation from the strict control of MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. Persistent activation of the JNK or p38 signaling pathways has been suggested to mediate neuronal apoptosis in AD, PD, and ALS, whereas the ERK signaling pathway plays a key role in several steps of tumorigenesis including cancer cell proliferation, migration, and invasion. In this review, we summarize recent findings on the roles of MAPK signaling pathways in human disorders, focusing on cancer and neurodegenerative diseases including AD, PD, and ALS.

Url:

https://hal.archives-ouvertes.fr/hal-00566733

DOI: 10.1016/j.bbadis.2009.12.009

Affiliations:

Corée du Sud

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to stream Hal, to step Curation: 000868
to stream Hal, to step Checkpoint: 000715
to stream Main, to step Merge: 001A39
to stream Main, to step Curation: 001929

Le document en format XML

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<term>TNF</term>
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<front><div type="abstract" xml:lang="en">The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular signal-regulated kinase (ERK), p38, and c-Jun NH-terminal kinase (JNK), with each MAPK signaling pathway consisting of at least three components, a MAPK kinase kinase (MAP3K), a MAPK kinase (MAP2K), and a MAPK. The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress. These signaling pathways regulate a variety of cellular activities including proliferation, differentiation, survival, and death. Deviation from the strict control of MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. Persistent activation of the JNK or p38 signaling pathways has been suggested to mediate neuronal apoptosis in AD, PD, and ALS, whereas the ERK signaling pathway plays a key role in several steps of tumorigenesis including cancer cell proliferation, migration, and invasion. In this review, we summarize recent findings on the roles of MAPK signaling pathways in human disorders, focusing on cancer and neurodegenerative diseases including AD, PD, and ALS.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Pathological roles of MAPK signaling pathways in human diseases

Pathological roles of MAPK signaling pathways in human diseases

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

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